Jackson Research Group

Group members (left to right)

Front: Yuri Lee, Adedamola Opalade, Helena Howell, Jaycee Mayfield

Back: Priya Singh, Timothy Jackson, Elizabeth Grotemeyer

About Us

Nature uses metalloenzymes containing Mn, Fe, or Cu and oxidants such as molecular oxygen and hydrogen peroxide to carry out remarkable oxidative transformations that are both vital for life and fascinating from a fundamental perspective. Such reactions also serve as inspiration for synthetic chemists, as catalytic processes that utilize earth-abundant metals are less expensive and more environmentally benign than conventional process that employ precious-metals. Our research focuses on using synthetic model complexes to understand the chemical reactions that are critical to the function of both metalloenzymes and earth-abundant metal catalysts. These reactions include activation of dioxygen (O2) and hydrogen peroxide (H2O2) and the cleavage of C-H and O-H bonds by high- and mid-valent metal-oxygen species. To achieve these goals, the Jackson lab uses a combination of i) synthetic and kinetic methods to generate and characterize the reactivity patterns of metal ion complexes, ii) detailed spectroscopic characterization of transition-metal species, and iii) computational chemistry. These combined efforts allow us to identify geometric and electronic properties of transition-metal complexes that influence chemical reactivity.

Spectroscopic methods used in our research include electronic absorption (UV-vis), electron paramagnetic resonance (EPR), magnetic circular dichroism (MCD), and X-ray absorption (XAS) spectroscopies. We also employ NMR methods to probe the solution structures of paramagnetic complexes. These tools are particularly powerful when used in conjunction with computational methods, as they permit the characterization of the geometric and electronic structures of fleeting intermediates too unstable to be characterized using standard crystallographic methods. Our lab also used kinetic studies to probe the reaction mechanisms of our complexes. By applying this three-pronged approach to bio-inspired transition-metal complexes, we gain detailed insight into how nature uses molecular oxygen and earth-abundant metals to oxidize substrates and apply this knowledge to develop transition metal complexes that can perform green oxidation reactions.

 

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Jackson Group News
Februrary 2021
Mechanistic insight into oxygen atom transfer reactions by mononuclear manganese(iv)–oxo adducts by Priya Singh, Eleanor Stewart-Jones, and Melissa Denler in Dalton Transactions
 
 
June 2020
Concerted proton–electron transfer reactions of manganese–hydroxo and manganese–oxo complexes by Jaycee Mayfield, and Elizabeth Grotemeyer in Chemical Communications
 
April 2020
Electronic Structure and Magnetic Properties of a Titanium(II) Coordination Complex by Gayan Wijeratne et al. in Inorganic Chemistry
 
 
Februrary 2020
Effect of Lewis Acids on the Structure and Reactivity of a Mononuclear Hydroxomanganese(III) Complex by Derek Rice, Elizabeth Grotemeyer, and Anna Donovan in Inorganic Chemistry
 
December 2019
Welcome to the group, Helena Howell!
 
Novermber 2019
Structural Characterization of a Series of N5-Ligated Mn-IV-Oxo Species by Allyssa Massie, Melissa Denler et al. in Chemistry-A European Journal
 
 
August 2019
Steric control of dixoygen activation pathways for MnII complexes supported by pentadentate, amide-containing ligands by Joshua Parham, Gayan Wijeratne, and Jaycee Mayfield in Dalton Transactions
 
July 2019
Congratulations to Joshua Parham, graduating with Ph.D!
 
June 2019
Congratulations to Melissa Denler, graduating with Ph.D with honors!
 
May 2019
Congratulations to Eleanor Stewart-Jones, receiving the Barry M. Goldwater Scholarship!
 
March 2019
MnIV-Oxo complex of a bis(benzimidazolyl)-containing N5 ligand reveals different reactivity trends for MnIV-oxo than FeIV-oxo species by Melissa Denler, Allyssa Massie, and Eleanor Stewart-Jones In Dalton Transactions
 
December 2018
Welcome to the group, Samuel Crowell and Priya Singh!
 
 
 
September 2018
MnIII-Peroxo adduct supported by a new tetradentate ligand shows acid-sensitive aldehyde deformylation reactivity by Melissa Denler, Gayan Wijeratne, Derek Rice, and Hannah Colmer In Dalton Transactions
 
 
 
May 2018
Congratulations to Allyssa Massie and Derek Rice, graduating with Ph.D with honors!
 
March 2018
ACS National meeting in New Orleans by Melissa Denler and Yuri Lee.
 
February 2018
Spectroscopic and Structural Characterization of Mn(III)-Alkylperoxo Complexes Supported by Pentadentate Amide-Containing Ligands by Joshua Parham, Gayan Wijeratne, and Derek Rice In Inorganic Chemistry
 
December 2017
Mn K-edge X-ray absorption studies of mononuclear Mn(III)-hydroxo complexes by Derek Rice and Gayan Wijeratne in Journal of Biological Inorganic Chemistry
 
Welcome to the group, Jaycee Mayfield and Elizabeth Grotemeyer!
 
October 2017 
Manganese-oxygen Intermediates in O-O Bond Activation and Hydrogen-Atom Transfer Reactions by Derek Rice and Allyssa Massie in Accounts of Chemical Research
 
April 2017
ACS National meeting in San Francisco by Derek Rice, Allyssa Massie, Melissa Denler, Joshua Parham, and Aruna Munasinghe.
 
March 2017
Equatorial Ligand Perturbations Influence the Reactivity of Manganese(IV)-Oxo Complexes by Allyssa Massie, Melissa Denler, et. al in Angewandte Chemi International Edition
 
December 2016
Welcome to the group, Yuri Lee!
 
November 2016
 
July 2016
Steric and Electronic Influence on Proton-Coupled Electron-Transfer Reactivity of a Mononuclear Mn(III)-Hydroxo Complex by Derek Rice, Gayan Wijeratne, Andrew Burr, and Josh Parham in Inorganic Chemistry
 
April 2016
Congratulations to Hannah Colmer, graduating with Ph.D with honors!
 
December 2015
Welcome to the group, Aruna Munasinghe!
 
June 2015
Welcome to the group, Melissa Denler!
 
June 2015
Congratulations to Gayan Wijeratne, graduating with Ph.D. with honors!
 
April 2015
Presentation by Gayan Wijeratne, "Dioxygen activation under ambient conditions using bio-inspired manganese(II) complexes to generate mid-valent oxidants for catalytic O–H bond oxidations," and poster presentation by Hannah Colmer, "Formation, Characterization, and O-O Bond Activation of a Bio-inspired Peroxomanganese(III) Complex," at 249th ACS National Meeting and Exposition, Denver, CO.
 
January 2015
"O–H bond oxidation by a monomeric Mn(III)–OMe complex" by Gayan Wijeratne published in Dalton Transactions
 
December 2014
Welcome to the group, Josh Parham!
 
November 2014
 
October 2014
July 2014

"Saturation Kinetics in Phenolic O–H Bond Oxidation by a Mononuclear Mn(III)–OH Complex Derived from Dioxygen" by Gayan Wijeratne and Briana Corzine published in Inorganic Chemistry

June 2014
 
June 2014
Domenick Leto graduates with Ph.D with honors
 
May 2014
 
January 2014
Poster presentation by Dr. Timothy Jackson at the Metals in Biology Gordon Research Conference and by Domenick Leto, Gayan Wijeratne, and Hannah Colmer at the Bioinorganic Gordon Research Seminar in Ventura, CA
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