Jackson Research Group

Group members (left to right)

Front: Aruna Munasinghe, Jaycee Mayfield, Allyssa Massie,

Eleanor Stewart-Jones, Shannon Jones, and Elizabeth Grotemeyer

Back: Andrew Burr, Derek Rice Anna Donovan, Melissa Denler,

Joshua Parham, Yuri Lee, Timothy Jackson

About Us

Nature uses metalloenzymes containing Mn, Fe, or Cu and oxidants such as molecular oxygen and hydrogen peroxide to carry out remarkable oxidative transformations that are both vital for life and fascinating from a fundamental perspective. Our research focuses on unraveling the reactivity of manganese-dependent enzymes that catalyze oxidative degradation reactions using molecular oxygen or hydrogen peroxide as oxidants. Our laboratory uses a combination of i) reactivity studies of metal ion complexes and enzymes, ii) detailed spectroscopic characterization of transition metal species, particularly unstable intermediates that cannot be characterized using X-ray crystallographic methods, and iii) computational chemistry.

Spectroscopic methods used in our research include electronic absorption (UV-vis), electron paramagnetic resonance (EPR), magnetic circular dichroism (MCD) spectroscopies, and X-ray absorption spectroscopy (XAS). These tools are particularly powerful when used in conjunction with computational methods, as they permit the characterization of the geometric and electronic structures of fleeting intermediates too unstable to be characterized using standard crystallographic methods. By applying this three-pronged approach to both metalloenzymes and transition metal complexes, we will gain detailed insight into how nature uses molecular oxygen and manganese to oxidize substrates and develop transition metal complexes that can perform "green" oxidation reactions.

Jackson Group News
December 2017
Mn K-edge X-ray absorption studies of mononuclear Mn(III)-hydroxo complexes by Derek Rice and Gayan Wijeratne in Journal of Biological Inorganic Chemistry
Welcome to the group, Jaycee Mayfield and Elizabeth Grotemeyer!
October 2017 
Manganese-oxygen Intermediates in O-O Bond Activation and Hydrogen-Atom Transfer Reactions by Derek Rice and Allyssa Massie in Accounts of Chemical Research
April 2017
ACS National meeting in San Francisco by Derek Rice, Allyssa Massie, Melissa Denler, Joshua Parham, and Aruna Munasinghe.
March 2017
Equatorial Ligand Perturbations Influence the Reactivity of Manganese(IV)-Oxo Complexes by Allyssa Massie, Melissa Denler, et. al in Angewandte Chemi International Edition
December 2016
Welcome to the group, Yuri Lee!
November 2016
July 2016
Steric and Electronic Influence on Proton-Coupled Electron-Transfer Reactivity of a Mononuclear Mn(III)-Hydroxo Complex by Derek Rice, Gayan Wijeratne, Andrew Burr, and Josh Parham in Inorganic Chemistry
April 2016
Congratulations to Hannah Colmer, graduating with Ph.D with honors!
December 2015
Welcome to the group, Aruna Munasinghe!
June 2015
Welcome to the group, Melissa Denler!
June 2015
Congratulations to Gayan Wijeratne, graduating with Ph.D. with honors!
April 2015
Presentation by Gayan Wijeratne, "Dioxygen activation under ambient conditions using bio-inspired manganese(II) complexes to generate mid-valent oxidants for catalytic O–H bond oxidations," and poster presentation by Hannah Colmer, "Formation, Characterization, and O-O Bond Activation of a Bio-inspired Peroxomanganese(III) Complex," at 249th ACS National Meeting and Exposition, Denver, CO.
January 2015
"O–H bond oxidation by a monomeric Mn(III)–OMe complex" by Gayan Wijeratne published in Dalton Transactions
December 2014
Welcome to the group, Josh Parham!
November 2014
October 2014
July 2014

"Saturation Kinetics in Phenolic O–H Bond Oxidation by a Mononuclear Mn(III)–OH Complex Derived from Dioxygen" by Gayan Wijeratne and Briana Corzine published in Inorganic Chemistry

June 2014
June 2014
Domenick Leto graduates with Ph.D with honors
May 2014
January 2014
Poster presentation by Dr. Timothy Jackson at the Metals in Biology Gordon Research Conference and by Domenick Leto, Gayan Wijeratne, and Hannah Colmer at the Bioinorganic Gordon Research Seminar in Ventura, CA
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