Jackson Research Group

Group members (left to right) Front: Josh Parham​, Anna Donovan, Melissa Denler, and Allyssa Massie  
Back: Derek Rice, Dr. Tim Jackson, Ryan Crist, Shannon Jones, and Aruna Munasinghe

(not pictured: Andrew Burr)

About Us

Nature uses metalloenzymes containing Mn, Fe, or Cu and oxidants such as molecular oxygen and hydrogen peroxide to carry out remarkable oxidative transformations that are both vital for life and fascinating from a fundamental perspective. Our research focuses on unraveling the reactivity of manganese-dependent enzymes that catalyze oxidative degradation reactions using molecular oxygen or hydrogen peroxide as oxidants. Our laboratory uses a combination of i) reactivity studies of metal ion complexes and enzymes, ii) detailed spectroscopic characterization of transition metal species, particularly unstable intermediates that cannot be characterized using X-ray crystallographic methods, and iii) computational chemistry.

Spectroscopic methods used in our research include electronic absorption (UV-vis), electron paramagnetic resonance (EPR), magnetic circular dichroism (MCD) spectroscopies, and X-ray absorption spectroscopy (XAS). These tools are particularly powerful when used in conjunction with computational methods, as they permit the characterization of the geometric and electronic structures of fleeting intermediates too unstable to be characterized using standard crystallographic methods. By applying this three-pronged approach to both metalloenzymes and transition metal complexes, we will gain detailed insight into how nature uses molecular oxygen and manganese to oxidize substrates and develop transition metal complexes that can perform "green" oxidation reactions.

Jackson Group News
April 2017
Poster presentations at the 253rd ACS National meeting in San Francisco by Derek Rice, Allyssa Massie, Melissa Denler, Joshua Parham, and Aruna Munasinghe.
March 2017
Equatorial Ligand Perturbations Influence the Reactivity of Manganese(IV)-Oxo Complexes by Allyssa Massie, Melissa Denler, et. al in Angewandte Chemi International Edition
December 2016
Welcome to the group, Yuri Lee!
November 2016
July 2016
Steric and Electronic Influence on Proton-Coupled Electron-Transfer Reactivity of a Mononuclear Mn(III)-Hydroxo Complex by Derek Rice, Gayan Wijeratne, Andrew Burr, and Josh Parham in Inorganic Chemistry
April 2016
Congratulations to Hannah Colmer, graduating with Ph.D with honors!
December 2015
Welcome to the group, Aruna Munasinghe!
June 2015
Welcome to the group, Melissa Denler!
June 2015
Congratulations to Gayan Wijeratne, graduating with Ph.D. with honors!
April 2015
Presentation by Gayan Wijeratne, "Dioxygen activation under ambient conditions using bio-inspired manganese(II) complexes to generate mid-valent oxidants for catalytic O–H bond oxidations," and poster presentation by Hannah Colmer, "Formation, Characterization, and O-O Bond Activation of a Bio-inspired Peroxomanganese(III) Complex," at 249th ACS National Meeting and Exposition, Denver, CO.
January 2015
"O–H bond oxidation by a monomeric Mn(III)–OMe complex" by Gayan Wijeratne published in Dalton Transactions
December 2014
Welcome to the group, Josh Parham!
November 2014
October 2014
July 2014

"Saturation Kinetics in Phenolic O–H Bond Oxidation by a Mononuclear Mn(III)–OH Complex Derived from Dioxygen" by Gayan Wijeratne and Briana Corzine published in Inorganic Chemistry

June 2014
June 2014
Domenick Leto graduates with Ph.D with honors
May 2014
January 2014
Poster presentation by Dr. Timothy Jackson at the Metals in Biology Gordon Research Conference and by Domenick Leto, Gayan Wijeratne, and Hannah Colmer at the Bioinorganic Gordon Research Seminar in Ventura, CA
November 2013
"Peroxomanganese complexes as an aid to understanding redox-active manganese enzymes" by Domenick Leto published in the Journal of Biological Inorganic Chemistry
July 2013
June 2013
Poster presentation by Hannah Colmer at the 2013 Regional Career Development Conference at the Chemistry-Biology Interface, Urbana-Champaign, IL, "Determining the Role of High-Valent Manganese Oxo and Hydroxo Intermediates in Biomimetic Systems"
April 2013
Dr. Timothy Jackson receives promotion to associate professor with tenure
April 2013
April 2013
April 2013
Presentation by Dr. Timothy Jackson at the 245th ACS National Meeting & Exposition, New Orleans, LA, "Spectroscopic and computational insights into manganese-dependent enzymes from studies of biomimetic manganese complexes"
November 2012
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